Dr. Gaurav Chhaya (Internal Medicine) needs a second opinion on this medical case.
Septic Thrombosis of the Cavernous Sinuses:- John R. Ebright, MD; Mitchell T. Pace, MD; Asher F. Niazi, MD Author Affiliations Article Information Arch Intern Med. 2001;161(22):2671-2676. doi:10.1001/archinte.161.22.2671 Abstract Septic thrombosis of the cavernous sinuses (or cavernous sinus thrombophlebitis [CST]) is a dramatic and potentially lethal illness, which is still occasionally seen by clinicians. Before the availability of antimicrobial agents, mortality from CST was near 100%, but it markedly decreased to approximately 20% to 30% during the antibiotic era.1,2 Nevertheless, the threat of death and serious morbidity continues to necessitate early recognition, diagnosis, and treatment of CST to minimize risks to the patient. Accordingly, we reviewed the salient clinical features of this illness, with emphasis on newer aspects of diagnosis and treatment. Anatomy Two cavernous sinuses are positioned on either side of the sella turcica, which contains the pituitary gland. These sinuses are connected by intercavernous sinuses located anterior and posterior to the sella. As is true for all dural venous sinuses, the cavernous sinuses are formed by a separation of the layers of dura mater (specifically, the meningeal and periosteal layers), with trabeculae from each layer crossing the spaces, giving them a reticular or cavernous structure. Immediately below, separated by very thin bone, are the sphenoid sinuses. Of great clinical importance is the intimate relationship of cranial nerves III, IV, V, and VI, which, accompanied by the horizontal segment of the internal carotid artery, run through the lumen in the cases of the artery and abducens nerve or through the outside layers of the cavernous sinuses' lateral walls in the cases of the oculomotor, trochlear, and ophthalmic maxillary branches of the trigeminal nerves.4,5 The cavernous sinuses extend from the superior orbital fissure in front backward to the petrous portion of the temporal bone. They receive blood from the superior ophthalmic and cerebral veins and the sphenoparietal sinuses and terminate posteriorly in the superior and inferior petrosal sinuses, which drain into the transverse sinuses and internal jugular veins. In addition, the cavernous sinuses are connected by emissary veins to the pterygoid plexus, which is adjacent to the deep muscles of the face, and also communicates with the deep facial and inferior ophthalmic veins. Pathogenesis The dural sinuses and the cerebral and emissary veins have no valves, which allows blood to flow in either direction according to pressure gradients in the vascular system. This fact and the extensive direct and indirect vascular connections of the centrally located cavernous sinuses make them vulnerable to septic thrombosis resulting from infection at multiple sites. Sinusitis, especially involving the sphenoid and ethmoid sinuses, seems to be the most common primary source of infection predisposing to CST. Infections arising at other locations, such as the face, nose, tonsils, soft palate, teeth (lower and upper), and ears, are less common primary sources since antibiotic therapy has become widely available. Orbital infection is rarely complicated by CST, although the ophthalmic veins drain directly into the orbits.6 The most common signs of CST are related to damage of the nerves that traverse the cavernous sinuses (including the parasympathetic and sympathetic nerves accompanying the oculomotor nerve and the internal carotid artery, respectively) and to engorgement of the retinal and orbital vessels caused by impaired venous drainage. It has been speculated that the trabeculated sinuses act like sieves, trapping bacteria, emboli, and thrombi progressing from anterior infected sites involving the nose, sinuses, or medial third of the face, or in a retrograde fashion from lateral venous sinuses, ears, or teeth. It is possible that more indolent, subacute cases arise from initially sterile thrombi that become infected after extending into the cavernous sinuses and that fulminant, acute cases result from rapid progression of an infected thrombus or septic embolization from a primary infected focus.7 Irrespective of which mechanism is involved, the presence of enlarging infected clots within a confined cavernous sinus spreading via intercavernous sinuses to involve the opposite side is an ominous complication. Systemic effects from sepsis, local effects from direct injury to cranial nerves III through VI and impaired vascular drainage from the face and eyes, and possible extension into adjacent tissue, causing meningitis, subdural empyema, and pituitary necrosis, together may result in an overwhelming and truly catastrophic illness. Microbiologic findings The most commonly identified pathogen in patients with CST continues to be Staphylococcus aureus, identified in 60% to 70% of patients. Less frequently identified are streptococcal species, including Streptococcus pneumoniae; gram-negative bacilli; and anerobes.3 Blood cultures are commonly positive (approximately 70% of cases), especially in patients with acute, fulminant disease, whereas cerebrospinal fluid, abnormal in most patients in terms of elevated white blood cell counts and protein levels, is culture positive in only approximately 20% of cases.8 Occasionally, fungi such as Aspergillus and members of the Mucoraceae family may cause CST.9-11 Clinical presentation Multiple clinical features varying in frequency and severity have been reported, with some, such as septic infarcts of other organs, becoming uncommon since the availability of antibiotic therapy. Another variable in this condition is the timing of the onset of signs and symptoms: patients with acute, fulminant disease will manifest most signs and symptoms rapidly from the outset of illness, and patients with a more subacute course will evidence the features listed in Table 1 sequentially and over several days. Nevertheless, most patients will develop fever, ptosis, proptosis, chemosis, and external ophthalmoplegia during the course of their illness. External ophthalmoplegia, defined as paralysis of the extraocular muscles (in the case of CST, secondary to dysfunction of cranial nerves III, IV, and VI, rather than direct involvement of the extraocular muscles), usually includes all the extraocular muscles. However, it may be more limited or present at least initially with only lateral rectus muscle palsy, especially when disease spreads to the opposite eye. Spread to the opposite eye through the intercavernous sinuses, usually within 24 to 48 hours of the initial unilateral periorbital edema, is a common and characteristic feature of CST. Less frequent, but still seen in most patients, are mild papilledema (usually a late finding), retinal venous engorgement, and altered mental status consisting of lethargy or obtundation. Headaches, an early symptom resulting from either sinusitis or CST, usually are frontal, temporal, or retro-orbital and may be accompanied by tearing. Violaceous edema of the upper lid accompanying periorbital swelling also is common. Decreased visual acuity, internal ophthalmoplegia, and periorbital sensory alteration secondary to trigeminal nerve (cranial nerve V) dysfunction have been reported in less than half of the patients. Internal ophthalmoplegia, defined as paralysis of the iris and ciliary apparatus, results from dysfunction of parasympathetic nerve fibers carried through the cavernous sinuses and optic canals on the oculomotor (cranial nerve III) nerves or dysfunction of the sympathetic fibers that join them to form the short ciliary nerves. As a result, the pupils may be dilated from parasympathetic paralysis or may be smaller and immobile if both parasympathetic and sympathetic fibers are involved. Sensory alteration within the distribution of the first division of the trigeminal nerve may present as hyperesthesia or hypoesthesia possibly with a depressed corneal response. Diplopia, seizures, and hemiparesis are uncommon.3,6 The clinical presentation may be made even more complex as a result of ischemic changes or extension of infection from the cavernous sinuses or primary site of infection to involve the adjacent vascular structures or brain parenchyma. Southwick et al3 reviewed the pathologic findings of 23 patients who died or underwent surgery during the antibiotic era. Extension of the thrombosis to other venous sinuses, including petrosal, inferior sagittal, sigmoid, and lateral, was observed in 7 patients. Such extension may not only worsen headache, obtundation, and papilledema but may also result in additional findings, such as ear and neck pain, odynophagia, dysphagia, hoarseness, lateral-gaze nystagmus, seizures, and hemiplegia. In addition, the same authors7 noted 4 cases of pituitary necrosis due to contiguous spread of infection or ischemic damage, 11 cases of meningitis, and 9 cases of brain abscess or subdural empyema, primarily in the frontoparietal or temporal lobes.3 Differential diagnosis Cavernous sinus thrombophlebitis is only 1 (albeit probably the most dramatic) of many causes of painful ophthalmoplegia. The most common condition mimicking acute CST is orbital cellulitis, which commonly causes periorbital swelling, proptosis, chemosis, ophthalmoplegia, fever, decreased vision, and pain.12 However, bilateral eye involvement, papilledema, decreased periocular sensation, dilated pupils, marked systemic toxic effects, and abnormal spinal fluid are much more likely to be features of CST and aid in differentiating the two conditions. Preseptal cellulitis, which does not cause proptosis and ophthalmoplegia, generally causes little confusion. Orbital apex syndrome, a rare complication of sinusitis, results from inflammation or infection involving 2 clefts in the bony posterior orbit: (1) the superior orbital fissure, which transmits cranial nerves III, IV, and VI and branches of the ophthalmic division of cranial nerve V, and the superior ophthalmic vein, and (2) the optic canal, through which pass the ophthalmic artery and optic nerve. This condition, compared with orbital cellulitis, more typically causes visual loss and ophthalmoplegia out of proportion to or preceding signs of anterior eye involvement, such as proptosis and periorbital edema. Because the optic nerve passes through the apex but not through the cavernous sinus, impaired vision is more common with the orbital apex syndrome than with CST.13,14 Other more indolent or chronic conditions may cause painful ophthalmoplegia owing to involvement of the cavernous sinuses, including local or metastatic malignancy; aseptic thrombosis resulting from trauma, myeloproliferative diseases, or dehydration; granulomatous disease, such as tuberculosis or fungal infection, sarcoid, syphilis, or Tolosa-Hunt syndrome; aneurysm of the internal carotid artery; or carotid-cavernous fistula. Other chronic diseases that may be confused with disease involving the cavernous sinuses are endocrine exophthalmos and ophthalmoplegic migraine.15-20 Diagnosis Before the availability of computed tomography (CT) or magnetic resonance imaging (MRI), CST was diagnosed by its clinical features or at autopsy. Occasionally, cerebral angiography or the more definitive orbital venography was performed, but it was accompanied, at least in the case of orbital venography, by the possibility of serious complications. It was difficult to puncture the frontal veins in patients who were acutely ill with facial edema; in addition, there was much concern that orbital venography, accomplished by injecting contrast material under pressure, may actually disseminate the infection or cause extension of the thrombosis.21 The availability of high-resolution enhanced CT scans and, more recently, MRI has remarkably improved our ability to establish the diagnosis of CST using noninvasive technology. Although there is currently some debate regarding which of the two is the procedure of first choice, most experience is with high-resolution CT performed with a slice thickness of 3 mm or less.22 Abnormal findings include those that are direct signs of CST, consisting of enlargement and expansion of the cavernous sinus with lateral wall flattening or convexity rather than normal concavity, best visualized on coronal images. In addition, multiple irregular or single large filling defects within the enhancing cavernous sinus are highly suggestive direct evidence for thrombi. This is particularly the case when the filling defects are irregular and do not correspond to the anatomic course of neural structures or a thrombosed intracavernous section of the internal carotid artery. They also must be differentiated from intracavernous fat deposits by size (thrombi usually >7 mm), density, and signal intensity.21-24 Indirect signs, related to concomitant venous obstruction, consist of dilation of the superior ophthalmic vein, exophthalmos, soft tissue edema, and thrombi visualized in the veins and sinuses tributary to the cavernous sinus (superior ophthalmic vein and superior petrosal, inferior petrosal, and sigmoid sinuses).21-24 Magnetic resonance imaging may be of greatest value either to reexamine patients with nondiagnostic CT scans or to further assess complications involving the pituitary gland or extension of infection into adjacent meninges or brain.21,22 We report a case of probable mucormycosis in which the organism seems to have invaded the cavernous sinuses from the paranasal sinuses to illustrate these points. Management and treatment Management of patients with CST must also include treatment of primary infections, such as sinusitis, dental abscesses, and facial cellulitis, and possible complications, including brain abscesses, meningitis, and extension to other venous sinuses. Initial antibiotic choice, while awaiting culture results, might consist of nafcillin sodium, metronidazole, and ceftriaxone sodium or cefotaxime sodium to treat the patient for the most common organisms associated with this disease. Vancomycin could be substituted for nafcillin if the risk of methicillin resistance is high. Doses should be high, appropriate for critically ill patients with intravascular and possible central nervous system infections. The duration of antibiotic therapy is not standardized, but 3 to 4 weeks, consistent with management of other intravascular infections, such as endotheliitis or suppurative phlebitis, seems to be a reasonable projection, especially if signs of inflammation, toxic effects, and fever have ceased during that period.25 Surgical drainage of the cavernous sinus is almost never performed, but surgery may be essential for the management of primary sinusitis or dental infection or complicating brain abscess, orbital abscess, or subdural empyema. Similarly, reduction of inflammation and edema by administering systemic corticosteroids is not a well-supported intervention in patients with CST. In a few patients, corticosteroid use may have contributed to improving cranial nerve dysfunction3,26 or persistent orbital congestion.27 Rarely, corticosteroid use may play a critical role in caring for patients with adrenal insufficiency secondary to ischemia or necrosis of the pituitary gland.28,29 Full anticoagulation using heparin, however, is possibly beneficial in select patients. Although no randomized controlled studies have been conducted (and because of the infrequency of this disease, probably never will be conducted), recent retrospective reviews provide some support for heparin use in the absence of cortical venous infarction. Anticoagulant therapy begun early (ie, within 7 days of hospitalization for CST) may reduce morbidity rates in survivors.30 In particular, a reduction in diplopia from cranial nerve dysfunction, unilateral blindness, seizures, hemiparesis, and hypopituitarism may be observed. The review by Southwick et al3 suggests that early anticoagulant therapy in patients with unilateral CST may also reduce mortality rates. Duration of anticoagulant therapy with warfarin sodium after initial heparin therapy is unknown, but 4 to 6 weeks has been suggested.30 Morbidity and mortality Mortality has decreased from 80% to 100% in the preantibiotic era to 20% to 30% since 1940. In addition, Yarington2 points to a decrease in morbidity from 50% to 75% to only 22%. Nevertheless, the threat of temporary complications and long-term sequelae remains. In a review published early in the antibiotic era, Shaw7 described 60 patients treated with either sulfonamides or penicillin: 53 recovered, but most (77%) had complications or long-term sequelae. Twenty-five patients had metastatic infection primarily involving the lungs, with abscesses, empyema, and pneumonia. Nine patients developed orbital abscesses and 5 developed abscesses in the brain. Prolonged cranial nerve dysfunction, especially of nerves III and VI, were the most common long-term sequelae; 5 patients developed unilateral blindness, and 4 had decreased visual acuity. Prominent facial veins and spastic paresis of the arm were also noted but were unusual.7 A more recent review3 of 96 patients treated since 1940 found 29 to have long-term sequelae, including oculomotor (cranial nerve III) weakness in 16 (17%) of 95 patients, blindness in 16 (17%), pituitary insufficiency in 2 (2%), and hemiparesis in 3 (3%). The cause of blindness has been speculated to be pressure on the retinal artery and vein at the orbital apex, arteritis of the internal carotid artery, emboli to the retinal artery, or toxic neuropathy of the optic nerve.31 Pituitary insufficiency, a rare but well-documented event, results from either infarction or extension of infection into the sella turcica.29 Hemiparesis may be a consequence of internal carotid artery occlusion, cerebral abscess, or cortical vein thrombosis.30 Conclusions Although rare, CST remains a dramatic and potentially lethal complication of infections involving the sinuses, face, ears, and oral cavity. Early recognition and differentiation from other diseases that can mimic it coupled with aggressive medical and possible surgical intervention are key to reducing mortality rates and long-term sequelae. Recent improvements in imaging, especially CT and MRI, have contributed substantially to the rapid diagnosis of this condition
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